Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation
Insulin receptor substrate (IRS)-1 is a major substrate of insulin-like growth factor (IGF)-I receptors.It is well-known that IGF-I and II play essential roles in myogenesis progression.Herein, we report an unexpected phenomenon that IRS-1-overexpressing L6 myoblasts are eliminated from normal cell layers at the beginning of differentiation.Initial